Bilayer Gastroretentive Modified-Release Tablets: A Quality-by-Design Approach to Achieving Precise Drug Release and Prolonged Gastric Retention

Bilayer gastroretentive modified-release (GR-MR) tablets offer a robust strategy to overcome rapid gastric emptying, ensuring precise release kinetics and enhanced bioavailability for drugs with site-specific absorption. This white paper applies a Quality-by-Design (QbD) framework to address the complexities of these systems, integrating an immediate-release (IR) layer with a gastroretentive extended-release (GR-ER) layer.

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