Solid-State NMR Analysis

Unambiguous Structural Characterization

Providing critical insights into molecular structure, intermolecular interactions, and solid-form behavior of APIs and drug products in the solid phase.

Insights

Direct Solid-State Identification

Polymorphs

Salt Forms

Solvates

Dispersions

Multidimensional Techniques

Advanced Analytical Suite

1D NMR Analysis

Evaluates local chemical environments and detects structural heterogeneity, including polymorphic transitions and amorphous content.

2D Correlation

Reveals molecular connectivity and intermolecular interactions within and across crystal lattices for detailed assignment.

Relaxation (T1/T2)

Quantifies molecular mobility and dynamics across APIs, intermediates, and final drug products in different states.

Versatile Nuclei Targeting

MAS & CP-MAS: Enhances spectral resolution and simplifies complex spectra for accurate interpretation.
Fluorine (¹⁹F): Highly sensitive detection enabling differentiation of polymorphs and amorphous phases.
Phosphorus (³¹P): Specialized applications for phosphorus-containing compounds and formulations.

Efficiency & Sensitivity

Sample Utilization: Reliable results from milligrams to low hundreds of milligrams.
LOD/LOQ: Flexible optimization of detection and quantification limits based on sample traits.
Signal-to-Noise: Enhanced ratios through advanced acquisition and optimized conditions.

Advancing Drug Development

From early-stage characterization through commercial development, ssNMR enables informed decision-making and reduces solid-state risks across the drug development lifecycle.

Achieve Your Success with Our Expertise

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Our capabilities span three specialized platforms:

Small Molecule
Crystal Bio Solutions
Crystal NAX

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