Crystallization Development

Robust & Scalable Process Design

The aim of a crystallization process development is to find a crystallization process which can stable produce the optimal solid form with all desired properties.

Primary Objective

Hitting Critical Quality Attributes (CQAs)

Designing stable and reproducible processes for optimal solid forms.

Chemical Purity

Organic impurities
Chiral upgrade
Residual solvents
Residual metal contents

Physical Form & Purity

Desired solid/crystal form
Undesired solid/crystal forms
Form inter-conversions

Physical Properties

Particle Size Distribution
Bulk Density
Particle Flow Property
Solubility & Hygroscopicity

End-to-End Support

Process Development Services

Method Selection

Evaluation of cooling vs. anti-solvent crystallization strategies.

Solvent Optimization

Precise selection based on solubility curves and metastable zones.

Form Control

Ensuring the desired polymorph is consistently and stably produced.

Parameter Tuning

Control over supersaturation, seeding, and addition rates.

Output Achievement

Delivering strict control over impurities, morphology, residual solvents, and PSD while maximizing overall productivity.

Achieve Your Success with Our Expertise

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Our capabilities span three specialized platforms:

Small Molecule
Crystal Bio Solutions
Crystal NAX

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